Guramrit Singh

Guramrit Singh

Guramrit Singh

Assistant Professor, Dept. of Molecular Genetics

singh.734@osu.edu

614-292-2640

276 Bioscience Building
484 W 12th Ave
Columbus, OH
43210

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Areas of Expertise

  • Gene Expression
  • RNA Processing
  • Control of mRNA Fate

Education

  • PhD: University of Colorado, Boulder

The major goal of research in the Singh lab is to understand how nuclear RNA processing shapes the composition and structure of messenger RNA-containing ribonucleoproteins (mRNPs) to eventually control mRNA fate in human cells. Current projects revolve around the exon junction complex (EJC), a stable mRNP component deposited on mRNA exon-exon junctions during pre-mRNA splicing. We employ an interdisciplinary approach that combines biochemical and cellular methodologies with quantitative high-throughput sequencing and proteomic technologies to investigate how nucleus-deposited EJC connects with cytoplasmic translation and mRNA degradation machineries. In collaboration with Dr. Sharon Amacher’s lab (Molecular Genetics, OSU), we are also developing zebrafish as a model system to study EJC functions during development.