The Schoenberg lab studies mRNA metabolism and translational control in mammalian cells. The major projects are: 1) regulation of endonucleases that catalyze mRNA decay, 2) estrogen regulation of mRNA turnover in breast cancer cells, 3) the relationship between re-capping of decapped or cleaved mRNAs to translation, cellular recovery from stress and cancer.
Five Recent Publications:
- Peng, Y. and Schoenberg, D.R. (2007) c-Src Activates Endonuclease-mediated mRNA Decay. Molecular Cell, 25: 779-787
- Otsuka, Y., Kedersha, N. and Schoenberg, D.R. (2009) Identification of a Cytoplasmic Complex that Adds a Cap Onto 5’-Monophosphate RNA. Molecular and Cellular Biology 29: 2155-2167.
- Peng, Y., Liu, X., Murray, E.L., Sarkar, M. and Schoenberg, D.R. (2009) The Cytoskeleton-associated Ena/VASP Proteins are Unanticipated Partners of the PMR1 mRNA Endonuclease. RNA 15: 576-587.
- Schoenberg, D.R. and Maquat, L.E. (2009) Re-capping the Message. Trends in Biochemical Sciences 34: 435-442.
- Schoenberg, D.R. (2011) Mechanisms of Endonuclease-mediated mRNA Decay. WIREs RNA 2: 582-600. DOI:10.1002/wrna.78.
Publication at PubMed