Current Projects:

Projects in the Chandler lab will focus on pre-mRNA splicing changes in response to stress; RNA binding protein modification and regulation; and mouse models for diseases involving RNA processing.

Five Recent Publications:

• Pierson, C.R., Dulin-Smith, A.N. Durban, A.N., Marshall, M.L., Marshall, J.T., Snyder, A.D., Naiyer, N., Gladman, J.T., Chandler, D.S., Lawlor, M.W., Buj-Bello, A., Dowling, J.J., and Beggs. A.H. Modeling the Human MTM1p.R69C Mutation in Murine Mtm1 Results in Exon 4 Skipping and a Less Severe Myotubular Myopathy Phenotype.  Human Molecular Genetics, 2011 Nov 18. [Epub ahead of print]
• Bebee, T.W., Gladman, J.T., Chandler, D.S. A tamoxifen inducible SMN mouse for temporal SMN replacement. Genesis.  2011 Dec;49(12):927-34.
• Gladman, J.T., Bebee, T.W., Edwards, C., Wang, X., Sahenk, Z., Rich, M.M., and Chandler, D.S. A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype.  Human Molecular Genetics 19(21): 4239-52, 2010.
• Gladman, J.T., and Chandler, D. S. Splicing of the SMN gene is regulated by conserved elements located in intron 7, Human Genetics, 126: 833–841, 2009.
• SinghR.K., Tapia-Santos, A., Bebee, T. W., and Chandler, D.S. Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress, Exp Cell Res 315(19): 3419-32, 2009.

Publication at PubMed