Irina Artsimovitch


Current projects:

We work on molecular mechanism of bacterial RNA polymerase and its regulation by accessory proteins, small ligands, nucleic acid signals, and antibiotics. Several projects are available; examples include (i) identification of cellular partners of a virulence factor RfaH by in vivo crosslinking; (ii) studies of the mechanism of RfaH re-folding in a tube; (iii)  dissection of RNA polymerase interactions with several transcription factors by genetic, biochemical, and biophysical approaches.

Five Recent Publications:

  • Deaconescu AM, Sevostyanova A, Artsimovitch I & Grigorieff N. (2012) NER machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface. Proc Natl Acad Sci U S A. in press
  • Furman R, Sevostyanova A & Artsimovitch I. (2011) Transcription initiation factor DksA has diverse effects on RNA chain elongation. Nucleic Acids Res. doi:10.1093/nar/gkr1273.
  • Artsimovitch I, Svetlov V, Nemetski SM, Epshtein V, Cardozo T & Nudler E. (2011) Tagetitoxin inhibits RNA polymerase through trapping of the trigger loop. J Biol Chem. 286, 40395-400.
  • Sevostyanova A, Belogurov GA, Mooney RA, Landick R & Artsimovitch I. (2011) The beta subunit gate loop is required for RNA polymerase modification by RfaH and NusG. Mol Cell. 43, 253-62.
  • Santangelo TJ & Artsimovitch I. (2011) Termination and antitermination: RNA polymerase runs a stop sign. Nat Rev Microbiol. 9, 319-29.

Publication at PubMed

  • Ph.D., 1996, Univ. of Tennessee

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Professor Irina Artsimovitch
The Ohio State University
Department of Microbiology
270 Aronoff
376 Biological Sciences Building
484 West 12th Avenue
Columbus, OH 43210-1292