Venkat Gopalan
Professor, Dept. of Chemistry & Biochemistry
707 Biosciences Building
484 W 12th Ave
Columbus, OH
43210
Google Map
Areas of Expertise
- Biochemistry
Education
- Ph.D., 1991, Biochemistry, University of New Mexico
Current Projects:
Utilize RNase P, a ribonucleoprotein involved in tRNA biogenesis, as a model system to understand protein-aided RNA catalysis - in particular, contribute to an ongoing project examining the role of ribosomal protein L7Ae in RNase P function in vitro and in vivo.
Screen and characterize various glycosyl hydrolases from endophytes to identify putative candidates that might be of value to the biofuel industry.
Five recent publications:
- Cho, I-M., Lai, L. B., Susanti, D., Mukhopadhyay, B., and Gopalan, V. (2010) Ribosomal protein L7Ae is a subunit of archaeal RNase P. Proc Natl Acad Sci USA 107, 14573-14578.
- Lai, L. B., Chan, P., Cozen, A., Bernick, D. L., Brown, J., Gopalan, V. and Lowe, T. (2010) Discovery of the elusive Pyrobaculum RNase P: an unexpected form of an ancient RNA. Proc Natl Acad Sci USA 107, 22493-22498.
- Chen W-Y., Pulukkunat D. K., Cho, I-M., Tsai, H-Y., and Gopalan V (2010) Dissecting functional cooperation among protein subunits in archaeal RNase P. Nucleic Acids Res 38, 8316-8327.
- Cho, I-M., Kazakov, S. A., Gopalan, V. (2011) Evidence for recycling of external guide sequences during cleavage of bipartite substrates by in vitro reconstituted archaeal RNase" P. J. Mol. Biol. 405, 1121-1127.
- Chen, W-Y,, Xu, Y,, Cho, I-M., Oruganti, S., Foster, M. P., Gopalan, V. (2011) Cooperative RNP assembly: Complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P. J Mol Biol 411, 368-383.