Current projects:

Projects in the Bisaro lab focus on  RNA-mediated silencing, including RNA-directed methylation, in plants;  suppression of silencing by viral proteins;  and the roles of metabolic defenses, including translation inhibition, in antiviral defense.

Five Recent Publications

• Zhu, Y., Cherukuri, N.C., Jackel, J.N., Wu, Z., Crary, M., Buckley, K., Bisaro, D.M., and Parris, D.S. (2012) Characterization of the RNA silencing suppressor activity of Ebola virus VP35 protein in plants and mammalian cells.  J. Virol: in press.
• Yang, X., Xie, Y., Raja, P., Li, S., Wolf, J.N., Shen, Q., Bisaro, D.M., and Zhou, X. (2011) Suppression of methylation-mediated transcriptional gene silencing by C1-SAHH protein interaction during geminivirus-betasatellite infection.  PLoS Path. 7: e1002329.
• Raja, P., Wolf, J.N., and Bisaro, D.M. (2010) RNA silencing directed against geminiviruses:  Post-transcriptional and epigenetic components.  Biochim. Biophys. Acta 1799: 337-351.
• Buchmann, R.C., Asad, S., Wolf, J.N., Mohannath, G., and Bisaro, D.M.  (2009) Geminivirus AL2 and L2 proteins suppress transcriptional gene silencing and cause genome-wide reductions in cytosine methylation.  J. Virol. 83: 5005-5013.
• Raja, P., Sanville, B.C., Buchmann, R.C., and Bisaro, D.M.  (2008) Viral genome methylation as an epigenetic defense against geminiviruses.  J. Virol. 82: 8997-9007.

Publications at PubMed